Human transforming growth factor- complementary DNA sequence and expression in normal and transformed cells
Identifieur interne : 004D96 ( Main/Exploration ); précédent : 004D95; suivant : 004D97Human transforming growth factor- complementary DNA sequence and expression in normal and transformed cells
Auteurs : Rik Derynck [États-Unis] ; Julie A. Jarrett [États-Unis] ; Ellson Y. Chen [États-Unis] ; Dennis H. Eaton [États-Unis] ; John R. Bell ; Richard K. Assoian ; Anita B. Roberts ; Michael B. Sporn ; David V. Goeddel [États-Unis]Source :
- Nature [ 0028-0836 ] ; 1985-08-22.
Abstract
The partial amino-acid sequence of purified human transforming growth factor- (TGF-) was used to identify a series of cDNA clones encoding the protein. The cDNA sequence indicates that the 112-amino acid monomeric form of the natural TGF- homodimer is derived proteolytically from a much longer precursor polypeptide which may be secreted. TGF- messenger RNA is synthesized in various normal and transformed cells.
Url:
DOI: 10.1038/316701a0
Affiliations:
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Chen</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Molecular Biology and Protein Biochemistry, Genentech Inc., 460 Point San Bruno Boulevard, South San Francisco, California 94080, USALaboratory of Chemoprevention, National Cancer Institute, Bethesda, Maryland 20205</wicri:regionArea><wicri:noRegion>Maryland 20205</wicri:noRegion></affiliation></author><author><name sortKey="Eaton, Dennis H" sort="Eaton, Dennis H" uniqKey="Eaton D" first="Dennis H." last="Eaton">Dennis H. Eaton</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Molecular Biology and Protein Biochemistry, Genentech Inc., 460 Point San Bruno Boulevard, South San Francisco, California 94080, USALaboratory of Chemoprevention, National Cancer Institute, Bethesda, Maryland 20205</wicri:regionArea><wicri:noRegion>Maryland 20205</wicri:noRegion></affiliation></author><author><name sortKey="Bell, John R" sort="Bell, John R" uniqKey="Bell J" first="John R." last="Bell">John R. Bell</name></author><author><name sortKey="Assoian, Richard K" sort="Assoian, Richard K" uniqKey="Assoian R" first="Richard K." last="Assoian">Richard K. Assoian</name></author><author><name sortKey="Roberts, Anita B" sort="Roberts, Anita B" uniqKey="Roberts A" first="Anita B." last="Roberts">Anita B. Roberts</name></author><author><name sortKey="Sporn, Michael B" sort="Sporn, Michael B" uniqKey="Sporn M" first="Michael B." last="Sporn">Michael B. Sporn</name></author><author><name sortKey="Goeddel, David V" sort="Goeddel, David V" uniqKey="Goeddel D" first="David V." last="Goeddel">David V. Goeddel</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Molecular Biology and Protein Biochemistry, Genentech Inc., 460 Point San Bruno Boulevard, South San Francisco, California 94080, USALaboratory of Chemoprevention, National Cancer Institute, Bethesda, Maryland 20205</wicri:regionArea><wicri:noRegion>Maryland 20205</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Nature</title><imprint><publisher>Nature Publishing Group</publisher><date when="1985-08-22">1985-08-22</date><biblScope unit="vol">316</biblScope><biblScope unit="issue">6030</biblScope><biblScope unit="page" from="701">701</biblScope><biblScope unit="page" to="705">705</biblScope><date type="Copyright" when="1985">1985</date></imprint><idno type="ISSN">0028-0836</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0028-0836</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The partial amino-acid sequence of purified human transforming growth factor- (TGF-) was used to identify a series of cDNA clones encoding the protein. The cDNA sequence indicates that the 112-amino acid monomeric form of the natural TGF- homodimer is derived proteolytically from a much longer precursor polypeptide which may be secreted. TGF- messenger RNA is synthesized in various normal and transformed cells.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Assoian, Richard K" sort="Assoian, Richard K" uniqKey="Assoian R" first="Richard K." last="Assoian">Richard K. Assoian</name><name sortKey="Bell, John R" sort="Bell, John R" uniqKey="Bell J" first="John R." last="Bell">John R. Bell</name><name sortKey="Roberts, Anita B" sort="Roberts, Anita B" uniqKey="Roberts A" first="Anita B." last="Roberts">Anita B. Roberts</name><name sortKey="Sporn, Michael B" sort="Sporn, Michael B" uniqKey="Sporn M" first="Michael B." last="Sporn">Michael B. 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